top of page

PUBLICATIONS

Under review
Jain HV et al., An efficient and flexible framework for inferring global sensitivity of agent-based model parameters.

Published papers
Bergman DA, Norton KA, Jain HV, Jackson TL. Connecting Agent-based Models with High-dimensional Parameter Spaces to Multidimensional Data Using SMoRe ParS - A Surrogate Modeling Approach, Bulletin of Mathematical Biology, 2024, 86:1
Jain HV, Norton K, Bianco-Prado B, Jackson TL. SMoRe ParS: A novel methodology for bridging modeling modalities and experimental data applied to 3D vascular tumor growth, Frontiers in Molecular Biosciences, 2022, 9:1056461.
Lapin A, Perfahl HP, Jain HV, Reuss M, Integrating a dynamic model for central metabolism of cancer cells with a hybrid 3D multiscale model for vascular hepatocellular carcinoma growth, Scientific Reports, 2022, 12:12373.
Barnaby JP, Jain HVCombining androgen deprivation and immunotherapy in prostate cancer treatment: a mechanistic approach, Applied Sciences, 2022, 12(14):6954.
Jain HV, Sorribes IC, Handelman SK, Barnaby JP, Jackson TL. Standing variations modeling captures inter-individual heterogeneity in a deterministic model of prostate cancer response to combination therapy, Cancers, 2021, 13(8):1872.
 
Barnaby JP, Sorribes IC, Jain HVRelating prostate-specific antigen leakage with vascular tumor growth in a mathematical model of prostate cancer response to androgen deprivation, Computational and Systems Oncology, 2021, 1:e1014.
Perfahl HP, Jain HV, Joshi T et al., Hybrid modelling of transarterial chemoembolisation therapies (TACE) for hepatocellular carcinoma (HCC), Scientific Reports, 2020, 10:10571.
 
Sorribes IC, Handelman SK, Jain HV, Mitigating temozolomide resistance in glioblastoma via DNA damage-repair inhibition, Journal of the Royal Society Interface, 2020, 17:20190722.
Sorribes IC, Moore MNJ, Byrne HM, Jain HV, A biomechanical model of tumor-induced intracranial pressure and edema in brain tissue, Biophysical Journal, 2019, 116:1560–1574.

 

Poole M, Sorribes IC, Jain HV, Modeling p53-HCV protein interactions in hepatocytes: Implications for carcinogenesis, Mathematical Biosciences, 2018, 306:186–196.

Jain HV, Jackson TL, Mathematical modeling of cellular cross-talk between endothelial and tumor cells highlights counterintuitive effects of VEGF-targeted therapies, Bulletin of Mathematical Biology, 2018, 80:971–1016.

Eisenberg M, Jain HV, Data and identifiability in models of cancer chemotherapy: a confidence building exercise, Journal of Theoretical Biology, 2017, 431:63–78.

Jain HV, Meyer-Hermann M, Richardson A, Byrne HM, Exploiting the synergy between carboplatin and ABT-737 in the treatment of ovarian carcinomas, PLoS ONE, 2014, 9(1):e81582.

Friedman A, Jain HV, A partial differential equation model of metastasized prostatic cancer, Mathematical Biosciences and Engineering, 2013, 10(3):591–608.

Jain HV, Jackson TL, A hybrid model of the role of VEGF binding in endothelial cell migration and capillary formation, Frontiers in Oncology, 2013, 3:102.

Jain HV, Friedman A, Modeling prostate cancer response to continuous versus intermittent androgen ablation therapy, Discrete and Continuous Dynamical Systems-B, 2013, 18(4):945–67.

Jain HV, Byrne HM, Qualitative analysis of an integro-differential equation model of periodic chemotherapy, Applied Mathematics Letters, 2012, 25(12):2132-6.

Jain HV, Moldovan NI, Byrne HM, Modelling stem/progenitor cell-induced neovascularization and oxygenation around solid implants, Tissue Engineering Part C Methods, 2012, 18(7):4497-501.

Jain HV, Clinton SK, Bhinder A, Friedman A, Mathematical modeling of prostate cancer progression in response to androgen ablation therapy, Proceedings of the National Academy of Sciences, 2011, 108(49):19701-6.

Jain HV, Meyer-Hermann M, The molecular basis of synergism between carboplatin and ABT-737 therapy targeting ovarian carcinomas, Cancer Research, 2011, 71(3):705-15.

Jain HV, Nor JE, Jackson TL, Quantification of endothelial cell-targeted anti Bcl-2 therapy and its suppression of tumor growth and vascularization, Molecular Cancer Therapeutics, 2009, 8(10):2926-36.

Jain HV, Nor JE, Jackson TL, Modelling the VEGF-Bcl-2-CXCL8 pathway in intra-tumoral angiogenesis, Bulletin of Mathematical Biology, 2008, 70(1):89-117.

Dong Z, Zeitlin BD, Song W, Sun Q, Karl, E, Spencer DM, Jain HV, Jackson TL, Nunez G, Nor JE, Level of endothelial apoptosis required for a significant decrease in microvessel density, Experimental Cellular Research, 2007, 313(16): 3645-3657.

Book chapters
Jain HV, Jackson TL, Linking EC stimulation to tumor growth and vascular density: The VEGF-Bcl2-CXCL8 pathway in Modeling Tumor Vasculature: Molecular, Cellular and Tissue Level Aspects and Implications, ed Jackson TL, Springer, pp 55-78.

 

Jackson TL, Ashkenazi R, Heusel S, Jain HV, Cancer modelling: A perspective on what’s new and what’s next in Mathematical Studies on Human Disease Dynamics: Emerging Paradigms and Challenges, eds Gumel A, Castillo-Chavez C, Mickens R and Clemens DP, Oxford University Press 40:229-234.

bottom of page