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Associate Professor
Director of Graduate Studies
Department of Mathematics & Statistics
University of Minnesota Duluth
PUBLICATIONS
Under review
Jain HV et al., An efficient and flexible framework for inferring global sensitivity of agent-based model parameters.
Jain HV et al., Advances in Surrogate Modeling for Biological Agent-Based Simulations: Trends, Challenges, and Future Prospects
Jain HV et al., Delaying Cancer Progression by Integrating Toxicity Constraints in a Model of Adaptive Therapy
Jain HV et al., Who’s In and Who’s Out: Leveraging Homogeneous Preclinical Data to Extrapolate Tumor Growth Outcomes Across Heterogeneous Populations
Published papers
Zhao S, Keller ET, Robinson T, Dai J, Ghose A, Alva A, Jackson TL, Jain HV. Evaluating PSA dynamics for predicting androgen deprivation failure with a patient specific prostate cancer model, NPJ Systems Biology and Applications, 2025, 86:1
Bergman DA, Norton KA, Jain HV, Jackson TL. Connecting Agent-based Models with High-dimensional Parameter Spaces to Multidimensional Data Using SMoRe ParS - A Surrogate Modeling Approach, Bulletin of Mathematical Biology, 2024, 86:1
Jain HV, Norton K, Bianco-Prado B, Jackson TL. SMoRe ParS: A novel methodology for bridging modeling modalities and experimental data applied to 3D vascular tumor growth, Frontiers in Molecular Biosciences, 2022, 9:1056461.
Lapin A, Perfahl HP, Jain HV, Reuss M, Integrating a dynamic model for central metabolism of cancer cells with a hybrid 3D multiscale model for vascular hepatocellular carcinoma growth, Scientific Reports, 2022, 12:12373.
Barnaby JP, Jain HV, Combining androgen deprivation and immunotherapy in prostate cancer treatment: a mechanistic approach, Applied Sciences, 2022, 12(14):6954.
Jain HV, Sorribes IC, Handelman SK, Barnaby JP, Jackson TL. Standing variations modeling captures inter-individual heterogeneity in a deterministic model of prostate cancer response to combination therapy, Cancers, 2021, 13(8):1872.
Barnaby JP, Sorribes IC, Jain HV, Relating prostate-specific antigen leakage with vascular tumor growth in a mathematical model of prostate cancer response to androgen deprivation, Computational and Systems Oncology, 2021, 1:e1014.
Perfahl HP, Jain HV, Joshi T et al., Hybrid modelling of transarterial chemoembolisation therapies (TACE) for hepatocellular carcinoma (HCC), Scientific Reports, 2020, 10:10571.
Sorribes IC, Handelman SK, Jain HV, Mitigating temozolomide resistance in glioblastoma via DNA damage-repair inhibition, Journal of the Royal Society Interface, 2020, 17:20190722.
Sorribes IC, Moore MNJ, Byrne HM, Jain HV, A biomechanical model of tumor-induced intracranial pressure and edema in brain tissue, Biophysical Journal, 2019, 116:1560–1574.
Poole M, Sorribes IC, Jain HV, Modeling p53-HCV protein interactions in hepatocytes: Implications for carcinogenesis, Mathematical Biosciences, 2018, 306:186–196.
Jain HV, Jackson TL, Mathematical modeling of cellular cross-talk between endothelial and tumor cells highlights counterintuitive effects of VEGF-targeted therapies, Bulletin of Mathematical Biology, 2018, 80:971–1016.
Eisenberg M, Jain HV, Data and identifiability in models of cancer chemotherapy: a confidence building exercise, Journal of Theoretical Biology, 2017, 431:63–78.
Jain HV, Meyer-Hermann M, Richardson A, Byrne HM, Exploiting the synergy between carboplatin and ABT-737 in the treatment of ovarian carcinomas, PLoS ONE, 2014, 9(1):e81582.
Friedman A, Jain HV, A partial differential equation model of metastasized prostatic cancer, Mathematical Biosciences and Engineering, 2013, 10(3):591–608.
Jain HV, Jackson TL, A hybrid model of the role of VEGF binding in endothelial cell migration and capillary formation, Frontiers in Oncology, 2013, 3:102.
Jain HV, Friedman A, Modeling prostate cancer response to continuous versus intermittent androgen ablation therapy, Discrete and Continuous Dynamical Systems-B, 2013, 18(4):945–67.
Jain HV, Byrne HM, Qualitative analysis of an integro-differential equation model of periodic chemotherapy, Applied Mathematics Letters, 2012, 25(12):2132-6.
Jain HV, Moldovan NI, Byrne HM, Modelling stem/progenitor cell-induced neovascularization and oxygenation around solid implants, Tissue Engineering Part C Methods, 2012, 18(7):4497-501.
Jain HV, Clinton SK, Bhinder A, Friedman A, Mathematical modeling of prostate cancer progression in response to androgen ablation therapy, Proceedings of the National Academy of Sciences, 2011, 108(49):19701-6.
Jain HV, Meyer-Hermann M, The molecular basis of synergism between carboplatin and ABT-737 therapy targeting ovarian carcinomas, Cancer Research, 2011, 71(3):705-15.
Jain HV, Nor JE, Jackson TL, Quantification of endothelial cell-targeted anti Bcl-2 therapy and its suppression of tumor growth and vascularization, Molecular Cancer Therapeutics, 2009, 8(10):2926-36.
Jain HV, Nor JE, Jackson TL, Modelling the VEGF-Bcl-2-CXCL8 pathway in intra-tumoral angiogenesis, Bulletin of Mathematical Biology, 2008, 70(1):89-117.
Dong Z, Zeitlin BD, Song W, Sun Q, Karl, E, Spencer DM, Jain HV, Jackson TL, Nunez G, Nor JE, Level of endothelial apoptosis required for a significant decrease in microvessel density, Experimental Cellular Research, 2007, 313(16): 3645-3657.
Book chapters
Jain HV, Jackson TL, Linking EC stimulation to tumor growth and vascular density: The VEGF-Bcl2-CXCL8 pathway in Modeling Tumor Vasculature: Molecular, Cellular and Tissue Level Aspects and Implications, ed Jackson TL, Springer, pp 55-78.
Jackson TL, Ashkenazi R, Heusel S, Jain HV, Cancer modelling: A perspective on what’s new and what’s next in Mathematical Studies on Human Disease Dynamics: Emerging Paradigms and Challenges, eds Gumel A, Castillo-Chavez C, Mickens R and Clemens DP, Oxford University Press 40:229-234.
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